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GSK / Cutivate
In controlled clinical trials of twice-daily administration, the total incidence of adverse reactions associated with the use of CUTIVATE Cream was approximately 4%. These adverse reactions were usually mild; self-limiting; and consisted primarily of pruritus, dryness, numbness of fingers, and burning. These events occurred in 2.9%, 1.2%, 1.0%, and 0.6% of patients, respectively.
Two clinical studies compared once- to twice-daily administration of CUTIVATE Cream for the treatment of moderate to severe eczema. The local drug-related adverse events for the 491 patients enrolled in both studies are shown in Table 1. In the study enrolling both adult and pediatric patients, the incidence of local adverse events in the 119 pediatric patients ages 1 to 12 years was comparable to the 140 patients ages 13 to 62 years.
How does it work?
This medicine contains the active ingredient fluticasone propionate, which is a type of medicine called a corticosteroid.
Corticosteroids are medicines used for reducing inflammation. Inflammation of the skin happens due to the irritation of the skin, and is caused by the release of various substances that are important in the immune system. These substances cause blood vessels to widen, resulting in the irritated area becoming red, swollen, itchy and painful.
When fluticasone is applied to the skin it works by acting inside the skin cells to decrease the release of these inflammatory substances. This reduces swelling, redness and itch. Fluticasone is a potent corticosteroid that is applied to the skin to treat a wide variety of inflammatory skin diseases, such as eczema.
The active ingredient is formulated in a moisturising base that provides a layer of oil on the surface of the skin, helping to prevent water from evaporating from the skin surface. This helps reduce the dryness, scaling and itching of skin conditions such as eczema.
What is it used for?
- An eruption of hard nodules in the skin accompanied by intense itching (prurigo nodularis)
- Area of thickened itchy skin caused by rubbing and scratching (lichen simplex)
- Eczema
- Inflammation or irritation of the skin caused by a reaction to irritants (contact dermatitis)
- Inflammatory skin condition with greasy, red and scaly areas (seborrhoeic dermatitis)
- Inflammatory skin disease known as discoid lupus erythematosus (DLE)
- Inflammatory skin disorders
- Intense and widespread reddening of the skin (generalised erythroderma) in combination with oral or injected corticosteroids
- Prickly heat
- Psoriasis
- Reactions to insect bites and stings
- Skin disorder causing a flat, itchy, violet rash, usually on the wrists, shins, lower back and genitals (lichen planus)
- Thickened skin rash caused by excessive scratching to relieve itching (neurodermatitis)
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